Sample size calculation – continuous outcome variable
نویسندگان
چکیده
منابع مشابه
Principles of sample size calculation
In most areas in life, it is difficult to work with populations and hence researchers work with samples. The calculation of the sample size needed depends on the data type and distribution. Elements include consideration of the alpha error, beta error, clinically meaningful difference, and the variability or standard deviation. The final number arrived at should be increased to include a safety...
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Addressing a sample size is a practical issue that has to be solved during planning and designing stage of the study. The aim of any clinical research is to detect the actual difference between two groups (power) and to provide an estimate of the difference with a reasonable accuracy (precision). Hence, researchers should do a priori estimate of sample size well ahead, before conducting the stu...
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optimum sample size is an essential component of any research. the main purpose of the sample size calculation is to determine the enough number of units needed to detect the unknown clinical parameters or the treatment effects or the association after data gathering. it is not uncommon for studies to be underpowered and failing to detect the existed treatment effects due to inadequate sample s...
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Sample size justification is an important consideration when planning a clinical trial, not only for the main trial but also for any preliminary pilot trial. When the outcome is a continuous variable, the sample size calculation requires an accurate estimate of the standard deviation of the outcome measure. A pilot trial can be used to get an estimate of the standard deviation, which could then...
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The number of samples needed to identify significant effects is a key question in biomedical studies, with consequences on experimental designs, costs and potential discoveries. In metabolic phenotyping studies, sample size determination remains a complex step. This is due particularly to the multiple hypothesis-testing framework and the top-down hypothesis-free approach, with no a priori known...
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ژورنال
عنوان ژورنال: The Southwest Respiratory and Critical Care Chronicles
سال: 2018
ISSN: 2325-9205
DOI: 10.12746/swrccc.v6i25.487